DPN™ (powder for IV infusion)

Contains per vial:

Diphosphopyridine nucleotide free acid hydrate 0,5g Pharmacological classification: A.9 Medicines against alcoholism.

We emphasize that DPN™ is only an adjuvant in the treatment of alcoholism. After the nervous system has been detoxified by the administration of DPN™, the craving for alcohol disappears, which gives the psychiatrist or psychologist a better chance to treat the patient.

Diphosphopyridine nucleotide (DPN™) is a naturally occurring co-enzyme, also known as NAD (Nicotinamide adenine dinucleotide). It is distributed normally throughout the tissues of the body and the highest concentration is usually in the liver. The main function is to act as a hydrogen carrier in anaerobic and aerobic oxidation and fermentation processes throughout the body.

Package Insert

Scheduling Status: S1

Proprietary name (and dosage form):

[DPN™ (powder for IV infusion)]

Composition:

Contains per vial: Diphosphopyridine nucleotide free acid hydrate 0,5g

Pharmacological classification:

A.9 Medicines against alcoholism

Pharmacological action:

DPN™ is a co-factor, which is responsible for the accelerated dehydrogenation of alcohol and acetaldehyde. The toxic metabolites of alcohol, such as acetaldehyde and aceto-acetic acid, are therefore removed from the nervous system.

Indications:

For detoxification in the excessive use of alcohol, amphetamines, barbiturates, opiates and other analgesics. For the prevention, alleviation and removal of the acute and chronic symptoms associated with alcoholism and drug abuse

Dosage and directions for use:

0,5 - 1,0g of DPN™ is dissolved in 200ml sterile sodium chloride solution (0,9%) and administered slowly by intravenous drip. The solution is administered on a daily basis and administrations can be repeated several times, depending on the toxic state of the patient. The normal rate of infusion should range between 20 - 140 µdrops/minute,

depending on the tolerance of the patient.

Side effects and special precautions:

Please ensure proper mix of the solution. Do not exceed 140 µdrops per minute. Where the rate of administration is too rapid, the patient may experience abdominal discomfort

and shortness of breath.

No drug or chemical agent should be co-administered in the DPN™ infusion line.

Identification:

White freeze-dried powder

Presentation:

Single dose amber glass vials containing 0,5g of white freeze-dried Diphosphopyridine nucleotide free acid hydrate, supplied in polystyrene container of 10 vials.

Storage instructions:

Store at 2 - 8 C.

Protect from light and moisture.

KEEP OUT OF REACH OF CHILDREN

Reference number:

G2931 (Act 101/1965)

Name and business address of applicant:

P O Box 32142, TOTIUSDAL, 0134

1046B Hertzog Street, Villeria, PRETORIA, 0186

Date of publication of this package insert:

September 1974

FOR MORE INFORMATION CONTACT ALCLIN, DOCTOR OR NEAREST REHABILITATION CENTRE :

Phone : 012-330 3162

Phone/Fax : 012-329 2912

Cell : 082-415 6656

Email: sales@alclin.co.za

For ordering of stock and trade inquiries contact: 1. South Africa TRANSFARM PHARMACEUTICAL WHOLESALER at :

(012) 377 9000,

or Alberta Germishuizen at TRANSFARM, Tel. (012) 377 9064, Fax (012) 377 9064

P O Box 23297, Gezina, 0031/ 387 Taljaard Street, Hermanstad, 0082.

The following information, research actions and discussions about Diphosphopyridine Nucleotide and DPN™ is intended for general information on the product only and does not constitute any medical claims whatsoever.